TG/HDL Ratio & Estimated HOMA-IR — Six-Year History
TG/HDL Ratio & Estimated HOMA-IR Over Time
Actual TG/HDL measurements (blue bars) with estimated HOMA-IR trend line (green) derived from TG/HDL correlation. HOMA-IR values are modelled, not measured.
Full Data Table with Clinical Interpretation
| Date | Triglycerides (mmol/L) |
HDL (mmol/L) |
TG/HDL Ratio | Est. HOMA-IR | IR Status |
|---|---|---|---|---|---|
| Sep 2019 | 3.73 | 1.18 | 3.16 | ~4.4 | Elevated IR |
| Nov 2020 | 5.83 | 1.27 | 4.59 | ~6.4 | Significant IR |
| Jul 2022 | 5.68 | 0.79 | 7.19 | ~10.1 | Critical IR — peak |
| Apr 2023 | 6.75 | 1.19 | 5.67 | ~7.9 | Very high IR |
| Jan 2024 | 3.14 | 1.35 | 2.33 | ~3.3 | Mild-moderate IR |
| Oct 2024 | 4.80 | 1.10 | 4.36 | ~6.1 | High IR — setback |
| Oct 2025 GAPS | 2.20 | 1.20 | 1.83 | ~2.6 | Borderline normal |
| Dec 2025 GAPS | 2.20 | 1.10 | 2.00 | ~2.8 | Borderline — mild elevation |
The trajectory is clinically remarkable. This client's TG/HDL ratio peaked at 7.19 in July 2022 — a level strongly associated with significant insulin resistance, elevated cardiovascular risk, and the metabolic driver of hypertension. The estimated HOMA-IR of approximately 10 at that point is consistent with advanced insulin resistance and represents a substantial cardiometabolic risk profile.
The January 2024 reading (TG/HDL 2.33, est. HOMA-IR ~3.3) was encouraging, but the October 2024 result (TG/HDL 4.36) shows the effect of periods of higher carbohydrate intake and occasional grains — the metabolic response is rapid and measurable.
Since January 2025 and the more consistent GAPS-based approach, the TG/HDL has fallen to 1.83–2.00 with an estimated HOMA-IR of approximately 2.6–2.8 — approaching the normal threshold of < 2.5 for the first time in the recorded history. For a 79-year-old with hypertension, this represents a genuinely significant metabolic improvement — one that in younger patients would typically correlate with meaningful reductions in blood pressure medication requirements.
Note: Estimated HOMA-IR values are derived from the TG/HDL correlation (HOMA-IR ≈ TG/HDL × 1.4) and are predictive, not measured. Actual HOMA-IR requires fasting glucose and fasting insulin blood tests. These estimates are consistent with published research correlating TG/HDL ratio with insulin resistance in mmol/L units.