Insulin Resistance & Chronic Disease

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Insulin Resistance & Chronic Disease — Evidence Summary
# Condition r (USA) r (UK) Strength USA Prevalence UK Prevalence USA Rise 1975–2022 UK Rise 1975–2022
1
All diagnosed high blood pressure
0.97 0.95 Dominant ~48%of adults ~30%of adults +24%25% → 31% diagnosed +15%26% → 30% diagnosed
2
Osteoarthritis & rheumatoid arthritis
0.87 0.83 Strong 58M~22% of adults ~10M~15% of adults +41%13.5% → 19.0% +70%10.0% → 17.0%
3
All diagnosed asthma
0.89 0.85 Strong 8.2%~27M adults 12%~8M adults +173%3.0% → 8.2% +50%8.0% → 12.0%
4
Irritable Bowel Syndrome
0.71 0.74 Moderate 13.5%~45M adults 15.5%~10M adults +42%9.5% → 13.5% +48%10.5% → 15.5%
5
"Type 3 Diabetes" — adults 65+
0.97 0.96 Dominant 10.9%of adults 65+ 7.9%of adults 65+ +142%4.5% → 10.9% (65+) +108%3.8% → 7.9% (65+)
6
Highest r in the series
0.98 0.97 Dominant 7.4%~25M adults 7.2%~4.3M adults +640%1.0% → 7.4% +620%1.0% → 7.2%
7
Including TIA / ischaemic stroke
0.96 0.95 Dominant 2.9%~7.5M adults 1.2%~1.3M adults +106%1.41% → 2.90% +134%0.50% → 1.17%
8
Attention Deficit Hyperactivity Disorder
0.94 0.91 Dominant 10.5%~26M adults & children 6.0%~4M adults & children +950%1.0% → 10.5% +1,900%0.3% → 6.0%
9
Per 100,000 population
0.96 0.97 Dominant 310per 100,000 240per 100,000 +377%65 → 310 per 100k +300%60 → 240 per 100k
10
Obsessive-Compulsive Disorder
0.73 0.76 Moderate 2.6%~6.5M adults 1.4%~0.9M adults +44%1.8% → 2.6% +27%1.1% → 1.4%
Strength key:   Dominant = r ≥ 0.90 — insulin resistance accounts for the overwhelming majority of the trend.   Strong = r 0.80–0.89 — insulin resistance is a major driver alongside other contributing factors.   Moderate = r 0.70–0.79 — meaningful relationship; other factors also significant.
Rise figures reflect the data series used in the individual condition analyses (1975–2022 unless noted). Alzheimer's figures are for adults 65+. MS figures are per 100,000 population. Ordering is by approximate number of people affected across the USA and UK combined.
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