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Insulin resistance is the silent metabolic dysfunction that precedes most chronic diseases by 5-20 years. While conventional medicine waits for blood sugar to rise into diabetic ranges, insulin resistance is already damaging your body—increasing inflammation, driving weight gain, and setting the stage for hypertension, type 2 diabetes, heart disease, and more. The good news? When detected early through HOMA-IR testing, insulin resistance is completely reversible through targeted lifestyle interventions that address the root cause.
What Leading Doctors Say About Intestinal Permeability and Insulin Resistance
Dr. Pradip Jamnadas, MD
Quote 1:
"The microbiome that is dysfunctional causes the integrity of your intestinal lining to be compromised. So now molecules that are supposed to stay in the gut, dead bacterial wall products, they call lipopolysaccharides... they get into the bloodstream, they go up the portal vein and up the portal vein, they'll end up going straight to the liver. There are basically three reasons for fatty liver. Either you're drinking too much alcohol or you get a leaky gut, or you have too much insulin, because insulin causes the conversion of glucose into fat."
Quote 2:
"When gut integrity is compromised, a condition known as leaky gut, harmful bacterial wall components such as lipopolysaccharides enter the bloodstream, travelling directly to the liver via the portal vein. This triggers fatty liver disease and systemic inflammation, both risk factors for coronary artery disease... Through dietary changes emphasising fibre, fermented foods, and supplements, the microbiome can be restored, inflammation lowered, and even the progression of arterial calcification slowed."
Dr. William Davis, MD
Quote 1:
"In 2007, Dr. Patrice Cani and colleagues... formally documented this phenomenon, showing that the increased entry of bacterial lipopolysaccharide (LPS) endotoxin into the bloodstream, 'endotoxemia,' was the driving factor in insulin resistance, weight gain, and type 2 diabetes... When blood levels of endotoxin increase, it triggers inflammation all throughout the body, along with insulin resistance, and is also directly toxic to various organs."
Quote 2:
"Weight gain and obesity—because endotoxemia is a major driver of insulin resistance, the process underlying weight gain, especially in the abdomen. Pre-diabetes and type 2 diabetes—While the doctor prescribes metformin, GLP-1 agonists like Ozempic, or insulin injections, he/she ignores a major underlying cause, SIBO and endotoxemia."
Dr. Pradip Jamnadas, MD
Quote 1:
"The microbiome that is dysfunctional causes the integrity of your intestinal lining to be compromised. So now molecules that are supposed to stay in the gut, dead bacterial wall products, they call lipopolysaccharides... they get into the bloodstream, they go up the portal vein and up the portal vein, they'll end up going straight to the liver. There are basically three reasons for fatty liver. Either you're drinking too much alcohol or you get a leaky gut, or you have too much insulin, because insulin causes the conversion of glucose into fat."
Quote 2:
"When gut integrity is compromised, a condition known as leaky gut, harmful bacterial wall components such as lipopolysaccharides enter the bloodstream, travelling directly to the liver via the portal vein. This triggers fatty liver disease and systemic inflammation, both risk factors for coronary artery disease... Through dietary changes emphasising fibre, fermented foods, and supplements, the microbiome can be restored, inflammation lowered, and even the progression of arterial calcification slowed."
Dr. William Davis, MD
Quote 1:
"In 2007, Dr. Patrice Cani and colleagues... formally documented this phenomenon, showing that the increased entry of bacterial lipopolysaccharide (LPS) endotoxin into the bloodstream, 'endotoxemia,' was the driving factor in insulin resistance, weight gain, and type 2 diabetes... When blood levels of endotoxin increase, it triggers inflammation all throughout the body, along with insulin resistance, and is also directly toxic to various organs."
Quote 2:
"Weight gain and obesity—because endotoxemia is a major driver of insulin resistance, the process underlying weight gain, especially in the abdomen. Pre-diabetes and type 2 diabetes—While the doctor prescribes metformin, GLP-1 agonists like Ozempic, or insulin injections, he/she ignores a major underlying cause, SIBO and endotoxemia."
These quotes clearly establish the intestinal permeability → endotoxemia → inflammation → insulin resistance pathway that both doctors emphasise in their work.
The Time Gap That Hides the Connection
Because insulin resistance typically develops years or even decades before diagnosable disease emerges, the connection between cause and effect often goes unrecognised. For example:
- Obsessive-compulsive disorder (OCD) may manifest in childhood—the same time insulin resistance can begin developing
- Individuals with larger body frames who experience persistent low mood or depression may be responding to underlying insulin resistance, yet only develop clinically diagnosed hypertension years or decades later
Signs of Insulin Resistance
Common conditions linked to insulin resistance can vary between men and women:
For men:
- Depression or persistent low mood
- Brain fog and cognitive difficulties
- Lack of motivation or drive
- Reduced stress resilience
- Poor sleep quality
- Increased fatigue
- Chronic low-grade inflammation
- Increased visceral (abdominal) fat
For Women:
- Irregular, unpredictable, or absent menstrual cycles
- Persistent hunger, even shortly after eating
- Brain fog and mental cloudiness
- Depression or persistent low mood
- Increased fatigue
- Chronic low-grade inflammation
- Increased visceral fat
The Solution -
Low-Carbohydrate Diet and Intermittent Fasting
A very low-carbohydrate diet combined with intermittent fasting directly addresses the root cause by lowering insulin levels and reversing insulin resistance.
The Research:
A systematic review found that low-carbohydrate diets produced significant reductions in blood pressure. BMJ Case Report: Ketogenic diet plus intermittent fasting reversed type 2 diabetes in 4 months, while eliminating hypertension medications within weeks—demonstrating rapid metabolic restoration addressing both conditions simultaneously.
Most importantly: These improvements occurred while improving metabolic health—the opposite of what happens with some medications that lower blood pressure while worsening insulin resistance. Here are studies that show hypertension and other diseases directly linked to insulin resistance.
How It Works:
- Reduced carbohydrate intake lowers insulin secretion
- Intermittent fasting enhances insulin sensitivity & cleans the cells through autophagy
- Together they reduce visceral fat—directly reversing the insulin resistance that contributes to arterial stiffening and hypertension
A very low-carbohydrate diet combined with intermittent fasting directly addresses the root cause by lowering insulin levels and reversing insulin resistance.
The Research:
A systematic review found that low-carbohydrate diets produced significant reductions in blood pressure. BMJ Case Report: Ketogenic diet plus intermittent fasting reversed type 2 diabetes in 4 months, while eliminating hypertension medications within weeks—demonstrating rapid metabolic restoration addressing both conditions simultaneously.
Most importantly: These improvements occurred while improving metabolic health—the opposite of what happens with some medications that lower blood pressure while worsening insulin resistance. Here are studies that show hypertension and other diseases directly linked to insulin resistance.
How It Works:
- Reduced carbohydrate intake lowers insulin secretion
- Intermittent fasting enhances insulin sensitivity & cleans the cells through autophagy
- Together they reduce visceral fat—directly reversing the insulin resistance that contributes to arterial stiffening and hypertension
The Supporting Evidence
Study 1: Zonulin and Insulin Resistance
Title: Circulating Zonulin, a Marker of Intestinal Permeability, Is Increased in Association with Obesity-Associated Insulin Resistance
Date: May 2012
Finding: This landmark study of 123 men demonstrated that circulating zonulin levels independently correlate with insulin resistance, even after controlling for body weight and other metabolic factors. The research revealed that insulin sensitivity directly contributes to zonulin variance (p = 0.002), and this relationship is mediated through IL-6—a key inflammatory cytokine that regulates zonulin expression. This was the first study to establish the direct link between metabolic dysfunction and intestinal barrier integrity.
Study 2: Zonulin's Mechanism of Action
Title: Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2
Date: September 2009
Finding: This groundbreaking molecular study identified zonulin as pre-haptoglobin-2 and demonstrated its mechanism of action. Researchers proved that zonulin directly causes increased intestinal permeability by activating EGFR through PAR2 receptors, leading to disassembly of tight junction proteins. In controlled experiments, recombinant zonulin increased gut permeability in a dose-dependent manner, while blocking PAR2 prevented barrier breakdown—establishing zonulin as the causal agent of leaky gut.
Study 3: Zonulin as Early Predictor of Diabetes
Title: Circulating zonulin levels in newly diagnosed Chinese type 2 diabetes patients
Date: September 2014
Finding: This study of 388 Chinese adults confirmed that zonulin levels are significantly elevated before Type 2 diabetes develops and are independently associated with insulin resistance (β = 0.024, p = 0.005). Zonulin emerged as an independent predictor of diabetes (OR = 1.080, p = 0.037), suggesting it could serve as an early warning biomarker. The research demonstrated that zonulin correlates with multiple markers of metabolic dysfunction including triglycerides, inflammatory cytokines, and HOMA-IR—reinforcing the central role of gut permeability in metabolic disease.
Study 1: Zonulin and Insulin Resistance
Title: Circulating Zonulin, a Marker of Intestinal Permeability, Is Increased in Association with Obesity-Associated Insulin Resistance
Date: May 2012
Finding: This landmark study of 123 men demonstrated that circulating zonulin levels independently correlate with insulin resistance, even after controlling for body weight and other metabolic factors. The research revealed that insulin sensitivity directly contributes to zonulin variance (p = 0.002), and this relationship is mediated through IL-6—a key inflammatory cytokine that regulates zonulin expression. This was the first study to establish the direct link between metabolic dysfunction and intestinal barrier integrity.
Study 2: Zonulin's Mechanism of Action
Title: Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2
Date: September 2009
Finding: This groundbreaking molecular study identified zonulin as pre-haptoglobin-2 and demonstrated its mechanism of action. Researchers proved that zonulin directly causes increased intestinal permeability by activating EGFR through PAR2 receptors, leading to disassembly of tight junction proteins. In controlled experiments, recombinant zonulin increased gut permeability in a dose-dependent manner, while blocking PAR2 prevented barrier breakdown—establishing zonulin as the causal agent of leaky gut.
Study 3: Zonulin as Early Predictor of Diabetes
Title: Circulating zonulin levels in newly diagnosed Chinese type 2 diabetes patients
Date: September 2014
Finding: This study of 388 Chinese adults confirmed that zonulin levels are significantly elevated before Type 2 diabetes develops and are independently associated with insulin resistance (β = 0.024, p = 0.005). Zonulin emerged as an independent predictor of diabetes (OR = 1.080, p = 0.037), suggesting it could serve as an early warning biomarker. The research demonstrated that zonulin correlates with multiple markers of metabolic dysfunction including triglycerides, inflammatory cytokines, and HOMA-IR—reinforcing the central role of gut permeability in metabolic disease.
Ready to Address the Root Cause?
You have three options to start your journey to genuine health restoration: