Integrative Remission for Type 2 Diabetes

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Key Summary

Insulin Resistance → Type 2 Diabetes:
– Insulin resistance precedes Type 2 diabetes by 10-15 years
– Insulin resistance is the most powerful predictor of Type 2 diabetes development
– Essential to the development of the majority of Type 2 diabetes cases
Diet and Fasting Achieve Remission:
– Low-carbohydrate diets achieve 57% remission vs. 31% for control diets at 6 months
– Remission rates up to 62% at one year with sustained dietary intervention
– Intermittent fasting combined with low-carb diet can eliminate insulin dependency
Patients reduce or eliminate medications while improving all metabolic markers
Expert Consensus: All three physicians (Jamnadas, Davis, Fung) agree that:
1. Insulin resistance is the root cause of Type 2 diabetes
2. Conventional treatment manages symptoms rather than addressing the cause
3. Very low-carbohydrate diets (eliminating grains and refined sugars) combined with intermittent fasting can produce complete remission
4. This approach is more effective than medication alone which only enables symptoms to be managed

The Root Cause of Type 2 Diabetes: Insulin Resistance

Type 2 diabetes is fundamentally a condition of insulin resistance, where cells become increasingly unresponsive to insulin’s signals. Yet conventional treatment focuses primarily on managing blood glucose levels rather than addressing this underlying insulin resistance. This approach attempts to manage symptoms without tackling the root cause and, in some cases, may even worsen insulin resistance over time.

Research demonstrates that prolonged reliance on glucose-management strategies can lead to complications involving inflammation and other side effects. The challenge is that reducing blood sugar without addressing insulin resistance fails to reverse the metabolic dysfunction driving the disease.

However, emerging evidence offers hope. Studies examining very low-carbohydrate diets—which eliminate refined sugar and grains, drastically reduce starchy foods, and incorporate intermittent fasting—have shown remarkable results. This dietary approach directly targets insulin resistance by minimising the glucose-insulin cycle that perpetuates the condition.

In several studies, participants following these protocols achieved Type 2 diabetes remission, with normalised blood glucose levels and reduced or eliminated medication requirements. By addressing insulin resistance at its source rather than merely managing its symptoms, this approach represents a fundamental shift in how we understand and treat Type 2 diabetes.

Dr. Pradip Jamnadas, MD
(Interventional Cardiologist) Quote 1 – On Insulin Resistance as Root Cause:
“The fundamental pathology in type 2 diabetes mellitus is insulin resistance. This means that the insulin molecule cannot act upon the insulin receptors in the body because the receptors have become insensitive. Therefore, it takes a lot of insulin production by the pancreas to stimulate the insulin receptors and thereby reduce the blood glucose to normal.”
Source: Cardiovascular Interventions Orlando website URL: Link to study
Dr. Pradip Jamnadas, MD
(Interventional Cardiologist) Quote 2 – On Fasting for Reversal:
“To restore insulin receptors sensitivity, the receptors must not be exposed to high insulin levels. The best way to do that is fasting. The pancreas produces most of the insulin upon eating with simple sugars stimulating insulin production the most. When the insulin level drops because of fasting, the receptors are no longer bombarded by so much insulin, and the insulin receptor sensitivity improves.”
Source: Cardiovascular Interventions Orlando website
URL: link to study

Dr. William Davis, MD (Cardiologist, Author of Wheat Belly)

Quote 1 – On Insulin Resistance Driving Disease:

“Insulin resistance is a fundamental process that drives many modern diseases. It is uncommon, for example, for someone to experience a heart attack if insulin resistance is not present. Insulin resistance is likewise the common thread among people who experience critical illness.”

Source: Dr. William Davis Infinite Health Blog
URL: link to study 

Dr. Pradip Jamnadas, MD
(Interventional Cardiologist) Quote 1 – On Insulin Resistance as Root Cause:
“The fundamental pathology in type 2 diabetes mellitus is insulin resistance. This means that the insulin molecule cannot act upon the insulin receptors in the body because the receptors have become insensitive. Therefore, it takes a lot of insulin production by the pancreas to stimulate the insulin receptors and thereby reduce the blood glucose to normal.”
Source: Cardiovascular Interventions Orlando website URL: Link to study

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Insulin resistance precedes most chronic diseases by 5-20 years (see peer-reviewed research that proves this ->)

- but it is not detected by NHS tests. A £149 HOMA-IR test can detect it while it is still completely reversible,

through a remission diet & fasting.

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