Here are summary of the published benefits of L. Reuteri:

Core Mechanisms of Action

L. reuteri produces antimicrobial molecules including organic acids, ethanol, and reuterin (a broad-spectrum antimicrobial substance), inhibits pathogenic microbes, strengthens intestinal barrier function, benefits the immune system by reducing pro-inflammatory cytokines while promoting regulatory T cell development, and remodels commensal microbiota composition .

Sources:

– <https://pmc.ncbi.nlm.nih.gov/articles/PMC5917019/>
– <https://synapse.patsnap.com/article/what-is-lactobacillus-reuteri-used-for>

Gastrointestinal Benefits

Infant Colic: Studies show colicky infants treated with L. reuteri experience significant reductions in crying time compared to simethicone or placebo, with multiple clinical trials confirming shorter crying episodes .

Sources:

– <https://healthpath.com/gut-health/lactobacillus-reuteri-dsm17938/>
– <https://en.wikipedia.org/wiki/Limosilactobacillus_reuteri>

Diarrhea: L. reuteri significantly reduces symptom duration in pediatric diarrheal disease and is effective as prophylaxis – children fed it while healthy are less likely to fall ill with diarrhea .

Source:

– <https://en.wikipedia.org/wiki/Limosilactobacillus_reuteri>

Inflammatory Bowel Disease: L. reuteri improves intestinal disorders by protecting the gut barrier, suppressing inflammation and immune response, regulating gut microbiota and metabolism, and inhibiting oxidative stress. Some strains can reduce the severity of experimental IBD through unique antioxidant properties .

Sources:

– <https://pmc.ncbi.nlm.nih.gov/articles/PMC9932687/>
 <https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2023.1095555/full>

Gut Barrier Function: L. reuteri 22 promotes intestinal stem cell differentiation into goblet cells with increased mucin 2 expression to ensure intestinal mucosal barrier functionality .

Sources:

– <https://pmc.ncbi.nlm.nih.gov/articles/PMC9932687/>
 <https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2023.1095555/full>

Cardiovascular Benefits

L. reuteri consumption significantly reduces total cholesterol concentration without affecting other cardiovascular disease risk factors in adults .

Source:

– <https://examine.com/supplements/lactobacillus-reuteri/>

Oral Health

L. reuteri kills Streptococcus mutans (responsible for tooth decay) and was the only tested probiotic species able to block it. Clinical trials showed people colonized with L. reuteri have significantly less S. mutans. Gingivitis patients showed decreased gum bleeding, plaque formation and other symptoms compared with placebo .

Source:

– <https://en.wikipedia.org/wiki/Limosilactobacillus_reuteri>

Mental Health & Brain Function

L. reuteri DSM 17938 produces GABA (a neurotransmitter promoting relaxation) and lowers C-reactive protein (inflammation marker), suggesting it may reduce stress-related inflammation and negative effects on mental and neurological health. It’s considered a psychobiotic supporting mental well-being .

Source:

– <https://healthpath.com/gut-health/lactobacillus-reuteri-dsm17938/>

Immune Function & General Wellness

Double-blind randomised studies in child care centres found L. reuteri-fed infants fall sick less often, require fewer doctor visits, and are absent fewer days compared to placebo and competing probiotics. Adults consuming L. reuteri daily fall ill 50% less often as measured by decreased sick leave use .

Source:

– <https://en.wikipedia.org/wiki/Limosilactobacillus_reuteri>

Safety Profile

The safety and tolerance of L. reuteri has been proven by numerous clinical studies.

Source:

– <https://pmc.ncbi.nlm.nih.gov/articles/PMC5917019/>