Research on Intestinal Permeability & Disease
Some published scientific literature providing extensive evidence linking increased intestinal permeability to both Type 2 Diabetes and High Blood Pressure.
Here are links to published papers (primarily review articles and original research) accessible through PubMed and scientific journal sites, which summarize or present data on this link:
1. Type 2 Diabetes Mellitus (T2DM) and Intestinal Permeability
These links describe the role of a “leaky gut” in systemic inflammation, insulin resistance, and T2DM development.
| Title | Publication Source (Link Type) | DOI/PMID |
|---|---|---|
| Leaky gut and diabetes mellitus: what is the link? | PubMed (Review) | https://pubmed.ncbi.nlm.nih. |
| Increased intestinal permeability as a risk factor for type 2 diabetes | ResearchGate (Original Study) | https://www.researchgate.net/ |
| Gut microbiome and type 2 diabetes: where we are and where to go? | PubMed (Review) | https://pubmed.ncbi.nlm.nih. |
| Increased intestinal-fatty acid binding protein in obesity-associated type 2 diabetes mellitus | PLOS ONE (Original Study) | https://journals.plos.org/ |
| Exploring the Significance of Gut Microbiota in Diabetes Pathogenesis and Management | MDPI (Review) | https://www.mdpi.com/2072- |
2. High Blood Pressure (Hypertension) and Intestinal Permeability
These links focus on the gut-brain axis, microbial metabolites, and gut barrier breakdown as drivers of hypertension.
| Title | Publication Source (Link Type) | DOI/PMID |
|---|---|---|
| Hypertension-Linked Pathophysiological Alterations in the Gut | PubMed Central (Original Study/Review) | https://pmc.ncbi.nlm.nih.gov/ |
| Hypertension-Linked Pathophysiological Alterations in the Gut | PubMed (Original Study/Review) | https://pubmed.ncbi.nlm.nih. |
| Gut Microbiome and Neuroinflammation in Hypertension | Circulation Research (Review) | https://www.ahajournals.org/ |
| Hypertension in rats is associated with an increased permeability of the colon to TMA, a gut bacteria metabolite | PLOS ONE (Original Study) | https://journals.plos.org/ |
| Biomarkers of intestinal permeability are linked to incident cardiovascular diseases and cardiovascular events | American Journal of Physiology (Review) | https://journals.physiology. |